1-Pyrrolidinecarboxylic Acid 1,1-DiMethylethyl Ester
tert-butyl 1-pyrrolidinecarboxylate
CAS: 86953-79-9
Molecular Formula: C9H17NO2
1-Pyrrolidinecarboxylic Acid 1,1-DiMethylethyl Ester - Names and Identifiers
1-Pyrrolidinecarboxylic Acid 1,1-DiMethylethyl Ester - Physico-chemical Properties
| Molecular Formula | C9H17NO2 |
| Molar Mass | 171.24 |
| Density | 0.977 g/mL at 25 °C (lit.) |
| Boling Point | 80 °C/0.2 mmHg (lit.) |
| Flash Point | 187°F |
| Solubility | Chloroform, Methanol |
| Vapor Presure | 0.107mmHg at 25°C |
| Appearance | Oil |
| Color | Clear Colorless |
| BRN | 4664750 |
| pKa | -1.28±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.449(lit.) |
1-Pyrrolidinecarboxylic Acid 1,1-DiMethylethyl Ester - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | NA 1993 / PGIII |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Note | Irritant |
1-Pyrrolidinecarboxylic Acid 1,1-DiMethylethyl Ester - Introduction
tert-butyl 1-Pyrrolidinecarboxylate (tert-butyl 1-Pyrrolidinecarboxylate) is an organic compound whose chemical formula is C10H19NO2.
Nature:
tert-butyl 1-pyrrolidinecarboxylate is a colorless liquid with a special fragrance. It has a density of about 0.91g/cm³ and a boiling point of 150-152°C.
Use:
tert-butyl 1-Pyrrolidinecarboxylate is commonly used as a protecting group in organic synthesis. It can react with the functional group of the target compound to undergo an esterification reaction, and form a reversible protecting group to protect the target functional group from interference from other reactions. If desired, the protecting group can be removed by the corresponding acid or base, restoring the original functional group of the target compound.
Preparation Method:
tert-butyl 1-pyrrolidinecarboxylate can be prepared by the following steps: First, tetrahydropyrrole is reacted with tert-butyl bromoacetate under alkaline conditions to generate the target product tert-butyl 1-pyrrolidinecarboxylate. After completion of the reaction, a pure product can be obtained by acid treatment.
Safety Information:
tert-butyl 1-Pyrrolidinecarboxylate is a stable compound under normal conditions, there may be a risk of explosion and fire when exposed to high temperatures, open flames or high energy conditions. It is a flammable liquid and should be kept away from sources of fire and high heat. At the same time, use should wear appropriate protective equipment, avoid skin contact and inhalation.
Nature:
tert-butyl 1-pyrrolidinecarboxylate is a colorless liquid with a special fragrance. It has a density of about 0.91g/cm³ and a boiling point of 150-152°C.
Use:
tert-butyl 1-Pyrrolidinecarboxylate is commonly used as a protecting group in organic synthesis. It can react with the functional group of the target compound to undergo an esterification reaction, and form a reversible protecting group to protect the target functional group from interference from other reactions. If desired, the protecting group can be removed by the corresponding acid or base, restoring the original functional group of the target compound.
Preparation Method:
tert-butyl 1-pyrrolidinecarboxylate can be prepared by the following steps: First, tetrahydropyrrole is reacted with tert-butyl bromoacetate under alkaline conditions to generate the target product tert-butyl 1-pyrrolidinecarboxylate. After completion of the reaction, a pure product can be obtained by acid treatment.
Safety Information:
tert-butyl 1-Pyrrolidinecarboxylate is a stable compound under normal conditions, there may be a risk of explosion and fire when exposed to high temperatures, open flames or high energy conditions. It is a flammable liquid and should be kept away from sources of fire and high heat. At the same time, use should wear appropriate protective equipment, avoid skin contact and inhalation.
Last Update：2024-04-10 22:29:15
